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Interactions médicamenteuses

Avanafil + Isosorbide mononitrate

Gravité: Contre-indiquée

Avanafil and Isosorbide mononitrate: contraindicated interaction.

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Résumé

Both avanafil and isosorbide mononitrate relax vascular smooth muscle through the nitric oxide-cGMP pathway. Their combination can cause profound, sometimes fatal, hypotension.

Ce que signifie cette interaction, en termes simples

Avanafil and Isosorbide mononitrate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Avanafil belongs to Genitourinary; Isosorbide mononitrate belongs to Cardiovascular.

Niveau de preuve: High

Pourquoi elle survient

PDE5 inhibition potentiates NO/cGMP vasodilation

Conduite à tenir

Contraindicated; do not give nitrates or nitroprusside within 12 hours of avanafil, and keep resuscitation capability available if nitrates are urgently needed later.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Avanafil with Isosorbide mononitrate?

MediHelp rates the interaction as contraindicated. Avanafil and Isosorbide mononitrate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both avanafil and isosorbide mononitrate relax vascular smooth muscle through the nitric oxide-cGMP pathway. Their combination can cause profound, sometimes fatal, hypotension.

How serious is the interaction between Avanafil and Isosorbide mononitrate?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Contraindicated; do not give nitrates or nitroprusside within 12 hours of avanafil, and keep resuscitation capability available if nitrates are urgently needed later.

What other medicines interact with Avanafil?

MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.

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