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Interactions médicamenteuses

Ergotamine + Isosorbide mononitrate

Gravité: Majeure

Ergotamine and Isosorbide mononitrate: major interaction.

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Résumé

Ergotamine causes vasoconstriction and can provoke angina or raise blood pressure, opposing the antianginal action of nitrates. Ergot derivatives may also reduce the effect of nitrates, and the clinical effect is a loss of antianginal efficacy.

Ce que signifie cette interaction, en termes simples

Ergotamine and Isosorbide mononitrate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Ergotamine belongs to Central Nervous System; Isosorbide mononitrate belongs to Cardiovascular.

Niveau de preuve: Moderate

Pourquoi elle survient

Pharmacodynamic antagonism between ergotamine vasoconstriction and nitrate vasodilation.

Conduite à tenir

Avoid in patients with coronary disease; choose a non-ergot migraine therapy that is safe in ischaemic heart disease where possible, and monitor for angina and blood pressure rise if unavoidable.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Ergotamine with Isosorbide mononitrate?

MediHelp rates the interaction as major. Ergotamine and Isosorbide mononitrate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ergotamine causes vasoconstriction and can provoke angina or raise blood pressure, opposing the antianginal action of nitrates. Ergot derivatives may also reduce the effect of nitrates, and the clinical effect is a loss of antianginal efficacy.

How serious is the interaction between Ergotamine and Isosorbide mononitrate?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in patients with coronary disease; choose a non-ergot migraine therapy that is safe in ischaemic heart disease where possible, and monitor for angina and blood pressure rise if unavoidable.

What other medicines interact with Isosorbide mononitrate?

MediHelp also lists interactions of Isosorbide mononitrate with, for example, Avanafil, Riociguat, Sildenafil. The full list is on the Isosorbide mononitrate page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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