Interactions médicamenteuses
Avapritinib + Imatinib
Gravité: Majeure
Avapritinib and Imatinib: major interaction.
Dernière mise à jour
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Résumé
Avapritinib is a CYP3A4 substrate, and imatinib is a moderate CYP3A4 inhibitor. Avapritinib exposure may increase, raising risks of cognitive effects, intracranial hemorrhage and edema. Both are kinase inhibitors, and imatinib is also used in GIST, where combination is not typical.
Ce que signifie cette interaction, en termes simples
Avapritinib and Imatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Avapritinib belongs to Oncology; Imatinib belongs to Oncology.
Pourquoi elle survient
CYP3A4 inhibition by imatinib reduces avapritinib clearance.
Conduite à tenir
Avoid the combination if possible. If necessary, use the reduced avapritinib starting dose from labeling and monitor for cognitive effects and bleeding.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Imatinib
- Imatinib + Lomitapide Contre-indiquée
- Imatinib + Lonafarnib Contre-indiquée
- Amobarbital + Imatinib Majeure
- Apalutamide + Imatinib Majeure
- Benzhydrocodone / acetaminophen + Imatinib Majeure
- Bosutinib + Imatinib Majeure
Autres interactions de Avapritinib
- Amobarbital + Avapritinib Majeure
- Apalutamide + Avapritinib Majeure
- Aprepitant + Avapritinib Majeure
- Armodafinil + Avapritinib Majeure
- Avapritinib + Bosentan Majeure
- Avapritinib + Carbamazepine Majeure
Questions fréquentes
Can I take Avapritinib with Imatinib?
MediHelp rates the interaction as major. Avapritinib and Imatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Avapritinib is a CYP3A4 substrate, and imatinib is a moderate CYP3A4 inhibitor. Avapritinib exposure may increase, raising risks of cognitive effects, intracranial hemorrhage and edema. Both are kinase inhibitors, and imatinib is also used in GIST, where combination is not typical.
How serious is the interaction between Avapritinib and Imatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If necessary, use the reduced avapritinib starting dose from labeling and monitor for cognitive effects and bleeding.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
