Interactions médicamenteuses
Benzhydrocodone / acetaminophen + Imatinib
Gravité: Majeure
Benzhydrocodone / acetaminophen and Imatinib: major interaction.
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Résumé
Benzhydrocodone is a prodrug of hydrocodone, which is metabolised by CYP3A4 to norhydrocodone. Imatinib inhibits CYP3A4, which can raise hydrocodone levels and increase sedation and respiratory depression.
Ce que signifie cette interaction, en termes simples
Benzhydrocodone / acetaminophen and Imatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
CYP3A4 inhibition by imatinib reduces hydrocodone clearance, with a minor contribution from CYP2D6 inhibition.
Conduite à tenir
Monitor closely for sedation and respiratory depression, and reduce the opioid dose if needed. Take care when imatinib is started or stopped.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Imatinib
- Imatinib + Lomitapide Contre-indiquée
- Imatinib + Lonafarnib Contre-indiquée
- Amobarbital + Imatinib Majeure
- Apalutamide + Imatinib Majeure
- Avapritinib + Imatinib Majeure
- Bosutinib + Imatinib Majeure
Questions fréquentes
Can I take Benzhydrocodone / acetaminophen with Imatinib?
MediHelp rates the interaction as major. Benzhydrocodone / acetaminophen and Imatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Benzhydrocodone is a prodrug of hydrocodone, which is metabolised by CYP3A4 to norhydrocodone. Imatinib inhibits CYP3A4, which can raise hydrocodone levels and increase sedation and respiratory depression.
How serious is the interaction between Benzhydrocodone / acetaminophen and Imatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for sedation and respiratory depression, and reduce the opioid dose if needed. Take care when imatinib is started or stopped.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
