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Interactions médicamenteuses

Imatinib + Lonafarnib

Gravité: Contre-indiquée

Imatinib and Lonafarnib: contraindicated interaction.

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Résumé

Lonafarnib is a sensitive CYP3A4 substrate, and imatinib inhibits CYP3A4. Increased lonafarnib exposure can worsen gastrointestinal toxicity, hepatic effects, and QT-related risks. Labeling contraindicates strong or moderate CYP3A inhibitors.

Ce que signifie cette interaction, en termes simples

Imatinib and Lonafarnib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Imatinib belongs to Oncology; Lonafarnib belongs to Miscellaneous.

Niveau de preuve: Moderate

Pourquoi elle survient

Imatinib inhibits CYP3A4 metabolism of lonafarnib, raising its systemic exposure.

Conduite à tenir

Avoid the combination. If a CYP3A inhibitor is essential, follow labeling for temporary lonafarnib dose reduction and monitor for toxicity.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Imatinib with Lonafarnib?

MediHelp rates the interaction as contraindicated. Imatinib and Lonafarnib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lonafarnib is a sensitive CYP3A4 substrate, and imatinib inhibits CYP3A4. Increased lonafarnib exposure can worsen gastrointestinal toxicity, hepatic effects, and QT-related risks. Labeling contraindicates strong or moderate CYP3A inhibitors.

How serious is the interaction between Imatinib and Lonafarnib?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. If a CYP3A inhibitor is essential, follow labeling for temporary lonafarnib dose reduction and monitor for toxicity.

What other medicines interact with Imatinib?

MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Amobarbital, Apalutamide. The full list is on the Imatinib page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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