Interactions médicamenteuses
Bosutinib + Imatinib
Gravité: Majeure
Bosutinib and Imatinib: major interaction.
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Résumé
Imatinib inhibits CYP3A4, the main enzyme clearing bosutinib, and can raise bosutinib exposure substantially. This increases the risk of bosutinib toxicity such as diarrhea, hepatotoxicity and myelosuppression. Both drugs are also BCR-ABL kinase inhibitors, so combining them offers little therapeutic rationale.
Ce que signifie cette interaction, en termes simples
Bosutinib and Imatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bosutinib belongs to Oncology; Imatinib belongs to Oncology.
Pourquoi elle survient
Imatinib inhibits CYP3A4-mediated metabolism of bosutinib, reducing its clearance.
Conduite à tenir
Avoid the combination and choose a single BCR-ABL inhibitor appropriate to the disease. If unavoidable, monitor liver enzymes and gastrointestinal and hematologic toxicity closely and reduce the bosutinib dose.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Imatinib
- Imatinib + Lomitapide Contre-indiquée
- Imatinib + Lonafarnib Contre-indiquée
- Amobarbital + Imatinib Majeure
- Apalutamide + Imatinib Majeure
- Avapritinib + Imatinib Majeure
- Benzhydrocodone / acetaminophen + Imatinib Majeure
Autres interactions de Bosutinib
- Amiodarone + Bosutinib Majeure
- Apalutamide + Bosutinib Majeure
- Aprepitant + Bosutinib Majeure
- Bosentan + Bosutinib Majeure
- Bosutinib + Carbamazepine Majeure
- Bosutinib + Chlorpromazine Majeure
Questions fréquentes
Can I take Bosutinib with Imatinib?
MediHelp rates the interaction as major. Bosutinib and Imatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Imatinib inhibits CYP3A4, the main enzyme clearing bosutinib, and can raise bosutinib exposure substantially. This increases the risk of bosutinib toxicity such as diarrhea, hepatotoxicity and myelosuppression. Both drugs are also BCR-ABL kinase inhibitors, so combining them offers little therapeutic rationale.
How serious is the interaction between Bosutinib and Imatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose a single BCR-ABL inhibitor appropriate to the disease. If unavoidable, monitor liver enzymes and gastrointestinal and hematologic toxicity closely and reduce the bosutinib dose.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
