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Interactions médicamenteuses

Avatrombopag + Secobarbital

Gravité: Modérée

Avatrombopag and Secobarbital: moderate interaction.

Dernière mise à jour

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Résumé

Secobarbital induces CYP3A4 and may induce CYP2C9, which can lower avatrombopag exposure and reduce the platelet response.

Ce que signifie cette interaction, en termes simples

Avatrombopag and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Avatrombopag belongs to Miscellaneous; Secobarbital belongs to Central Nervous System.

Niveau de preuve: Moderate

Pourquoi elle survient

Induction of CYP3A4 and CYP2C9 increases avatrombopag clearance.

Conduite à tenir

Monitor platelet counts and follow the labeled dose increase for ITP when combined with inducers. Reassess the dose when the barbiturate is stopped.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Avatrombopag with Secobarbital?

MediHelp rates the interaction as moderate. Avatrombopag and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Secobarbital induces CYP3A4 and may induce CYP2C9, which can lower avatrombopag exposure and reduce the platelet response.

How serious is the interaction between Avatrombopag and Secobarbital?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor platelet counts and follow the labeled dose increase for ITP when combined with inducers. Reassess the dose when the barbiturate is stopped.

What other medicines interact with Secobarbital?

MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.

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