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Interactions médicamenteuses

Doravirine + Secobarbital

Gravité: Contre-indiquée

Doravirine and Secobarbital: contraindicated interaction.

Dernière mise à jour

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Résumé

Barbiturates induce CYP3A4 and can substantially lower doravirine concentrations. This risks loss of virologic suppression and development of resistance. Doravirine labeling advises against strong CYP3A inducers.

Ce que signifie cette interaction, en termes simples

Doravirine and Secobarbital are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Doravirine belongs to Anti Virals; Secobarbital belongs to Central Nervous System.

Niveau de preuve: Moderate

Pourquoi elle survient

Barbiturate-mediated CYP3A4 induction increases doravirine metabolism.

Conduite à tenir

Avoid the combination and use a non-inducing hypnotic or sedative. If an inducer is unavoidable, use an alternative antiretroviral regimen.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Doravirine with Secobarbital?

MediHelp rates the interaction as contraindicated. Doravirine and Secobarbital are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Barbiturates induce CYP3A4 and can substantially lower doravirine concentrations. This risks loss of virologic suppression and development of resistance. Doravirine labeling advises against strong CYP3A inducers.

How serious is the interaction between Doravirine and Secobarbital?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-inducing hypnotic or sedative. If an inducer is unavoidable, use an alternative antiretroviral regimen.

What other medicines interact with Secobarbital?

MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Elbasvir / grazoprevir, Elvitegravir / cobicistat / emtricitabine / tenofovir df. The full list is on the Secobarbital page.

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