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Interactions médicamenteuses

Lonafarnib + Secobarbital

Gravité: Contre-indiquée

Lonafarnib and Secobarbital: contraindicated interaction.

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Résumé

Lonafarnib is a sensitive CYP3A4 substrate, so enzyme induction by secobarbital can greatly reduce its exposure. This could cause loss of efficacy. Labeling prohibits use with strong or moderate CYP3A inducers.

Ce que signifie cette interaction, en termes simples

Lonafarnib and Secobarbital are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Lonafarnib belongs to Miscellaneous; Secobarbital belongs to Central Nervous System.

Niveau de preuve: Moderate

Pourquoi elle survient

Barbiturate-mediated CYP3A4 induction increases lonafarnib metabolism.

Conduite à tenir

Avoid the combination. Select a non-inducing alternative to secobarbital.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Lonafarnib with Secobarbital?

MediHelp rates the interaction as contraindicated. Lonafarnib and Secobarbital are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lonafarnib is a sensitive CYP3A4 substrate, so enzyme induction by secobarbital can greatly reduce its exposure. This could cause loss of efficacy. Labeling prohibits use with strong or moderate CYP3A inducers.

How serious is the interaction between Lonafarnib and Secobarbital?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. Select a non-inducing alternative to secobarbital.

What other medicines interact with Secobarbital?

MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.

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