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Interactions médicamenteuses

Azathioprine + Pretomanid

Gravité: Majeure

Azathioprine and Pretomanid: major interaction.

Dernière mise à jour

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Résumé

Pretomanid-containing regimens are associated with liver toxicity, and azathioprine can also cause hepatic injury. Using them together raises the risk of hepatotoxicity.

Ce que signifie cette interaction, en termes simples

Azathioprine and Pretomanid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Azathioprine belongs to Gastrointestinal Tract; Pretomanid belongs to Anti Bacterial.

Niveau de preuve: Low

Pourquoi elle survient

Additive hepatotoxicity from two drugs with independent liver injury potential.

Conduite à tenir

Avoid azathioprine during pretomanid regimens when possible. If both are needed, monitor liver enzymes and bilirubin regularly and interrupt therapy if significant injury develops.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Azathioprine with Pretomanid?

MediHelp rates the interaction as major. Azathioprine and Pretomanid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pretomanid-containing regimens are associated with liver toxicity, and azathioprine can also cause hepatic injury. Using them together raises the risk of hepatotoxicity.

How serious is the interaction between Azathioprine and Pretomanid?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid azathioprine during pretomanid regimens when possible. If both are needed, monitor liver enzymes and bilirubin regularly and interrupt therapy if significant injury develops.

What other medicines interact with Azathioprine?

MediHelp also lists interactions of Azathioprine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Febuxostat. The full list is on the Azathioprine page.

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