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MediHelp Référence médicamenteuse

Interactions médicamenteuses

Baricitinib + Vadadustat

Gravité: Modérée

Baricitinib and Vadadustat: moderate interaction.

Dernière mise à jour

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Résumé

Vadadustat inhibits the organic anion transporter 3 (OAT3), which is a major route of renal elimination for baricitinib. Co-administration can raise baricitinib exposure and may increase dose-related adverse effects such as infection, cytopenias and lipid changes.

Ce que signifie cette interaction, en termes simples

Baricitinib and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Baricitinib belongs to Musculoskeletal; Vadadustat belongs to Endocrine.

Niveau de preuve: Moderate

Pourquoi elle survient

Vadadustat inhibits OAT3-mediated renal tubular secretion of baricitinib, reducing its clearance.

Conduite à tenir

Monitor for baricitinib adverse effects, including infections and blood counts. Consider baricitinib dose reduction according to its labeling for OAT3 inhibitors.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Baricitinib with Vadadustat?

MediHelp rates the interaction as moderate. Baricitinib and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vadadustat inhibits the organic anion transporter 3 (OAT3), which is a major route of renal elimination for baricitinib. Co-administration can raise baricitinib exposure and may increase dose-related adverse effects such as infection, cytopenias and lipid changes.

How serious is the interaction between Baricitinib and Vadadustat?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for baricitinib adverse effects, including infections and blood counts. Consider baricitinib dose reduction according to its labeling for OAT3 inhibitors.

What other medicines interact with Baricitinib?

MediHelp also lists interactions of Baricitinib with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Tofacitinib. The full list is on the Baricitinib page.

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