Drug interactions
Baricitinib + Vadadustat
Severity: Moderate
Baricitinib and Vadadustat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vadadustat inhibits the organic anion transporter 3 (OAT3), which is a major route of renal elimination for baricitinib. Co-administration can raise baricitinib exposure and may increase dose-related adverse effects such as infection, cytopenias and lipid changes.
What this interaction means in plain words
Baricitinib and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baricitinib belongs to Musculoskeletal; Vadadustat belongs to Endocrine.
Why it happens
Vadadustat inhibits OAT3-mediated renal tubular secretion of baricitinib, reducing its clearance.
What to do
Monitor for baricitinib adverse effects, including infections and blood counts. Consider baricitinib dose reduction according to its labeling for OAT3 inhibitors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Baricitinib
- Adenovirus types 4 and 7 live + Baricitinib Contraindicated
- Baricitinib + Bcg vaccine live Contraindicated
- Baricitinib + Tofacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Abatacept + Baricitinib Major
- Adalimumab + Baricitinib Major
Other interactions of Vadadustat
- Atorvastatin + Vadadustat Moderate
- Balsalazide + Vadadustat Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Calcium carbonate + Vadadustat Moderate
- Calcium + Vadadustat Moderate
- Cladribine + Vadadustat Moderate
Frequently asked questions
Can I take Baricitinib with Vadadustat?
MediHelp rates the interaction as moderate. Baricitinib and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vadadustat inhibits the organic anion transporter 3 (OAT3), which is a major route of renal elimination for baricitinib. Co-administration can raise baricitinib exposure and may increase dose-related adverse effects such as infection, cytopenias and lipid changes.
How serious is the interaction between Baricitinib and Vadadustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for baricitinib adverse effects, including infections and blood counts. Consider baricitinib dose reduction according to its labeling for OAT3 inhibitors.
What other medicines interact with Baricitinib?
MediHelp also lists interactions of Baricitinib with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Tofacitinib. The full list is on the Baricitinib page.
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