Interactions médicamenteuses
Bcg vaccine live + Leflunomide
Gravité: Contre-indiquée
Bcg vaccine live and Leflunomide: contraindicated interaction.
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Résumé
Leflunomide-induced immunosuppression can allow a live attenuated vaccine strain to replicate uncontrolled, causing disseminated infection. The vaccine response may also be diminished.
Ce que signifie cette interaction, en termes simples
Bcg vaccine live and Leflunomide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
Suppressed lymphocyte function impairs control of live attenuated organisms.
Conduite à tenir
Avoid live vaccines during leflunomide therapy and until drug elimination is confirmed (washout with cholestyramine if needed); give them before starting treatment.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Leflunomide
- Influenza virus vaccine quadrivalent intranasal + Leflunomide Contre-indiquée
- Leflunomide + Measles mumps and rubella vaccine live Contre-indiquée
- Leflunomide + Measles mumps rubella and varicella vaccine live Contre-indiquée
- Leflunomide + Measles vaccine Contre-indiquée
- Leflunomide + Smallpox vaccine live Contre-indiquée
- Alefacept + Leflunomide Majeure
Questions fréquentes
Can I take Bcg vaccine live with Leflunomide?
MediHelp rates the interaction as contraindicated. Bcg vaccine live and Leflunomide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Leflunomide-induced immunosuppression can allow a live attenuated vaccine strain to replicate uncontrolled, causing disseminated infection. The vaccine response may also be diminished.
How serious is the interaction between Bcg vaccine live and Leflunomide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live vaccines during leflunomide therapy and until drug elimination is confirmed (washout with cholestyramine if needed); give them before starting treatment.
What other medicines interact with Leflunomide?
MediHelp also lists interactions of Leflunomide with, for example, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Leflunomide page.
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