Interactions médicamenteuses
Influenza virus vaccine quadrivalent intranasal + Leflunomide
Gravité: Contre-indiquée
Influenza virus vaccine quadrivalent intranasal and Leflunomide: contraindicated interaction.
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Résumé
The intranasal influenza vaccine contains live attenuated virus, which may replicate more readily in a patient immunosuppressed by leflunomide. This could cause vaccine-strain infection and the response may be reduced.
Ce que signifie cette interaction, en termes simples
Influenza virus vaccine quadrivalent intranasal and Leflunomide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
Impaired lymphocyte function reduces control of live attenuated virus replication.
Conduite à tenir
Avoid the live intranasal vaccine; use an inactivated injectable influenza vaccine instead.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Leflunomide
- Bcg vaccine live + Leflunomide Contre-indiquée
- Leflunomide + Measles mumps and rubella vaccine live Contre-indiquée
- Leflunomide + Measles mumps rubella and varicella vaccine live Contre-indiquée
- Leflunomide + Measles vaccine Contre-indiquée
- Leflunomide + Smallpox vaccine live Contre-indiquée
- Alefacept + Leflunomide Majeure
Questions fréquentes
Can I take Influenza virus vaccine quadrivalent intranasal with Leflunomide?
MediHelp rates the interaction as contraindicated. Influenza virus vaccine quadrivalent intranasal and Leflunomide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. The intranasal influenza vaccine contains live attenuated virus, which may replicate more readily in a patient immunosuppressed by leflunomide. This could cause vaccine-strain infection and the response may be reduced.
How serious is the interaction between Influenza virus vaccine quadrivalent intranasal and Leflunomide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the live intranasal vaccine; use an inactivated injectable influenza vaccine instead.
What other medicines interact with Leflunomide?
MediHelp also lists interactions of Leflunomide with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Leflunomide page.
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