Interactions médicamenteuses
Bcg vaccine live + Lomustine
Gravité: Contre-indiquée
Bcg vaccine live and Lomustine: contraindicated interaction.
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Résumé
Lomustine suppresses bone marrow and immune function, so live BCG may cause disseminated BCG infection. Vaccine efficacy is also reduced.
Ce que signifie cette interaction, en termes simples
Bcg vaccine live and Lomustine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
Cytotoxic immunosuppression impairs control of live vaccine bacteria and reduces the immune response.
Conduite à tenir
Avoid BCG vaccination during lomustine therapy and until immune recovery, generally at least 3 months after stopping. Seek specialist advice if exposure risk is high.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Lomustine
- Adenovirus types 4 and 7 live + Lomustine Contre-indiquée
- Influenza virus vaccine quadrivalent intranasal + Lomustine Contre-indiquée
- Lomustine + Measles mumps and rubella vaccine Contre-indiquée
- Lomustine + Measles mumps and rubella vaccine live Contre-indiquée
- Lomustine + Measles mumps rubella and varicella vaccine live Contre-indiquée
- Lomustine + Measles vaccine Contre-indiquée
Questions fréquentes
Can I take Bcg vaccine live with Lomustine?
MediHelp rates the interaction as contraindicated. Bcg vaccine live and Lomustine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lomustine suppresses bone marrow and immune function, so live BCG may cause disseminated BCG infection. Vaccine efficacy is also reduced.
How serious is the interaction between Bcg vaccine live and Lomustine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid BCG vaccination during lomustine therapy and until immune recovery, generally at least 3 months after stopping. Seek specialist advice if exposure risk is high.
What other medicines interact with Lomustine?
MediHelp also lists interactions of Lomustine with, for example, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine. The full list is on the Lomustine page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
