Drug interactions
Bcg vaccine live + Lomustine
Severity: Contraindicated
Bcg vaccine live and Lomustine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomustine suppresses bone marrow and immune function, so live BCG may cause disseminated BCG infection. Vaccine efficacy is also reduced.
What this interaction means in plain words
Bcg vaccine live and Lomustine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Cytotoxic immunosuppression impairs control of live vaccine bacteria and reduces the immune response.
What to do
Avoid BCG vaccination during lomustine therapy and until immune recovery, generally at least 3 months after stopping. Seek specialist advice if exposure risk is high.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Lomustine
- Adenovirus types 4 and 7 live + Lomustine Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Lomustine Contraindicated
- Lomustine + Measles mumps and rubella vaccine Contraindicated
- Lomustine + Measles mumps and rubella vaccine live Contraindicated
- Lomustine + Measles mumps rubella and varicella vaccine live Contraindicated
- Lomustine + Measles vaccine Contraindicated
Frequently asked questions
Can I take Bcg vaccine live with Lomustine?
MediHelp rates the interaction as contraindicated. Bcg vaccine live and Lomustine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lomustine suppresses bone marrow and immune function, so live BCG may cause disseminated BCG infection. Vaccine efficacy is also reduced.
How serious is the interaction between Bcg vaccine live and Lomustine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid BCG vaccination during lomustine therapy and until immune recovery, generally at least 3 months after stopping. Seek specialist advice if exposure risk is high.
What other medicines interact with Lomustine?
MediHelp also lists interactions of Lomustine with, for example, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine. The full list is on the Lomustine page.
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