Interactions médicamenteuses
Bcg vaccine live + Melphalan
Gravité: Contre-indiquée
Bcg vaccine live and Melphalan: contraindicated interaction.
Dernière mise à jour Sources: UK SmPC
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Résumé
BCG vaccine contains live attenuated mycobacteria, which can disseminate in immunosuppressed patients and cause systemic BCG infection. Melphalan-induced immunosuppression increases this risk.
Ce que signifie cette interaction, en termes simples
Bcg vaccine live and Melphalan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
Immunosuppression from melphalan impairs control of live attenuated bacteria and reduces the vaccine response.
Conduite à tenir
Do not give BCG vaccine during melphalan therapy or for at least 3 months afterward. Defer vaccination until immune recovery.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Références
Autres interactions de Melphalan
- Adenovirus types 4 and 7 live + Melphalan Contre-indiquée
- Influenza virus vaccine quadrivalent intranasal + Melphalan Contre-indiquée
- Measles mumps and rubella vaccine live + Melphalan Contre-indiquée
- Measles mumps and rubella vaccine + Melphalan Contre-indiquée
- Measles mumps rubella and varicella vaccine live + Melphalan Contre-indiquée
- Measles vaccine + Melphalan Contre-indiquée
Questions fréquentes
Can I take Bcg vaccine live with Melphalan?
MediHelp rates the interaction as contraindicated. Bcg vaccine live and Melphalan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. BCG vaccine contains live attenuated mycobacteria, which can disseminate in immunosuppressed patients and cause systemic BCG infection. Melphalan-induced immunosuppression increases this risk.
How serious is the interaction between Bcg vaccine live and Melphalan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give BCG vaccine during melphalan therapy or for at least 3 months afterward. Defer vaccination until immune recovery.
What other medicines interact with Melphalan?
MediHelp also lists interactions of Melphalan with, for example, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Melphalan page.
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