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Interactions médicamenteuses

Measles mumps and rubella vaccine + Melphalan

Gravité: Contre-indiquée

Measles mumps and rubella vaccine and Melphalan: contraindicated interaction.

Dernière mise à jour Sources: UK SmPC

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Résumé

Melphalan causes marked myelosuppression and immunosuppression, so live attenuated vaccine viruses may replicate unchecked and cause disseminated infection. Vaccine efficacy is also reduced.

Ce que signifie cette interaction, en termes simples

Measles mumps and rubella vaccine and Melphalan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Measles mumps and rubella vaccine belongs to Miscellaneous; Melphalan belongs to Oncology.

Niveau de preuve: Moderate

Pourquoi elle survient

Cytotoxic immunosuppression permits uncontrolled replication of live attenuated virus.

Conduite à tenir

Avoid live vaccines during melphalan therapy; give them only after immune recovery, usually at least 3 months after stopping.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Références

Questions fréquentes

Can I take Measles mumps and rubella vaccine with Melphalan?

MediHelp rates the interaction as contraindicated. Measles mumps and rubella vaccine and Melphalan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Melphalan causes marked myelosuppression and immunosuppression, so live attenuated vaccine viruses may replicate unchecked and cause disseminated infection. Vaccine efficacy is also reduced.

How serious is the interaction between Measles mumps and rubella vaccine and Melphalan?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live vaccines during melphalan therapy; give them only after immune recovery, usually at least 3 months after stopping.

What other medicines interact with Measles mumps and rubella vaccine?

MediHelp also lists interactions of Measles mumps and rubella vaccine with, for example, Adalimumab, Anakinra, Antithymocyte globulin equine. The full list is on the Measles mumps and rubella vaccine page.

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