Interactions médicamenteuses
Influenza virus vaccine quadrivalent intranasal + Melphalan
Gravité: Contre-indiquée
Influenza virus vaccine quadrivalent intranasal and Melphalan: contraindicated interaction.
Dernière mise à jour Sources: UK SmPC
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Résumé
The intranasal influenza vaccine contains live attenuated virus, which can replicate excessively in a patient immunosuppressed by melphalan. The vaccine response is also reduced.
Ce que signifie cette interaction, en termes simples
Influenza virus vaccine quadrivalent intranasal and Melphalan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
Chemotherapy-induced immunosuppression allows unchecked replication of live attenuated virus and impairs the vaccine response.
Conduite à tenir
Use an inactivated injectable influenza vaccine instead during melphalan therapy. Avoid the live intranasal product until at least 3 months after treatment ends.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Références
Autres interactions de Melphalan
- Adenovirus types 4 and 7 live + Melphalan Contre-indiquée
- Bcg vaccine live + Melphalan Contre-indiquée
- Measles mumps and rubella vaccine live + Melphalan Contre-indiquée
- Measles mumps and rubella vaccine + Melphalan Contre-indiquée
- Measles mumps rubella and varicella vaccine live + Melphalan Contre-indiquée
- Measles vaccine + Melphalan Contre-indiquée
Questions fréquentes
Can I take Influenza virus vaccine quadrivalent intranasal with Melphalan?
MediHelp rates the interaction as contraindicated. Influenza virus vaccine quadrivalent intranasal and Melphalan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. The intranasal influenza vaccine contains live attenuated virus, which can replicate excessively in a patient immunosuppressed by melphalan. The vaccine response is also reduced.
How serious is the interaction between Influenza virus vaccine quadrivalent intranasal and Melphalan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an inactivated injectable influenza vaccine instead during melphalan therapy. Avoid the live intranasal product until at least 3 months after treatment ends.
What other medicines interact with Melphalan?
MediHelp also lists interactions of Melphalan with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Measles mumps and rubella vaccine live. The full list is on the Melphalan page.
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