Interactions médicamenteuses
Measles mumps rubella and varicella vaccine live + Melphalan
Gravité: Contre-indiquée
Measles mumps rubella and varicella vaccine live and Melphalan: contraindicated interaction.
Dernière mise à jour Sources: UK SmPC
Réservé aux professionnels de santé — à titre de référence uniquement. Cette page est un bref résumé, pas un avis médical, et ne remplace ni la notice officielle ni le jugement clinique. Vérifiez toujours avant de prescrire ou de délivrer.
Le contenu clinique de cette page n'est disponible qu'en anglais.
Résumé
MMRV vaccine contains live attenuated viruses, which can replicate without control in a patient immunosuppressed by melphalan. This can lead to disseminated vaccine-virus disease, and the vaccine response is also reduced.
Ce que signifie cette interaction, en termes simples
Measles mumps rubella and varicella vaccine live and Melphalan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
Chemotherapy-induced immunosuppression allows unchecked replication of live attenuated virus and impairs the vaccine response.
Conduite à tenir
Avoid live vaccines during melphalan therapy and for at least 3 months after it ends, subject to immune recovery. Give live vaccines at least 4 weeks before starting chemotherapy when possible.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Réservé aux membres Pro+
Débloquer la page complète
Créez un compte et lancez un essai Pro+ pour débloquer les conseils complets de prise en charge pour Measles mumps rubella and varicella vaccine live et Melphalan, les notes complémentaires, le détail des données probantes et le vérificateur d'interactions pour une ordonnance complète.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Essayez Pro+ gratuitement pendant 7 jours sur le web. Sans carte.
Références
Autres interactions de Melphalan
- Adenovirus types 4 and 7 live + Melphalan Contre-indiquée
- Bcg vaccine live + Melphalan Contre-indiquée
- Influenza virus vaccine quadrivalent intranasal + Melphalan Contre-indiquée
- Measles mumps and rubella vaccine live + Melphalan Contre-indiquée
- Measles mumps and rubella vaccine + Melphalan Contre-indiquée
- Measles vaccine + Melphalan Contre-indiquée
Questions fréquentes
Can I take Measles mumps rubella and varicella vaccine live with Melphalan?
MediHelp rates the interaction as contraindicated. Measles mumps rubella and varicella vaccine live and Melphalan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. MMRV vaccine contains live attenuated viruses, which can replicate without control in a patient immunosuppressed by melphalan. This can lead to disseminated vaccine-virus disease, and the vaccine response is also reduced.
How serious is the interaction between Measles mumps rubella and varicella vaccine live and Melphalan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live vaccines during melphalan therapy and for at least 3 months after it ends, subject to immune recovery. Give live vaccines at least 4 weeks before starting chemotherapy when possible.
What other medicines interact with Melphalan?
MediHelp also lists interactions of Melphalan with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Melphalan page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
