Interactions médicamenteuses
Benazepril + Empagliflozin-linagliptin
Gravité: Modérée
Benazepril and Empagliflozin-linagliptin: moderate interaction.
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Résumé
DPP-4 inhibitors such as linagliptin reduce breakdown of substance P and bradykinin, which are also affected by ACE inhibitors. Taking both may raise the risk of angioedema, though absolute risk remains small.
Ce que signifie cette interaction, en termes simples
Benazepril and Empagliflozin-linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Empagliflozin-linagliptin belongs to Endocrine.
Pourquoi elle survient
Additive reduction in bradykinin and substance P degradation through ACE and DPP-4 inhibition.
Conduite à tenir
Counsel the patient to report swelling of the lips, tongue or face immediately. Stop the ACE inhibitor and treat if angioedema occurs, and use an alternative antihypertensive class in patients with prior angioedema.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Empagliflozin-linagliptin
Autres interactions de Benazepril
- Aliskiren + Benazepril Contre-indiquée
- Benazepril + Sacubitril / valsartan Contre-indiquée
- Benazepril + Sacubitril-valsartan Contre-indiquée
- Amifostine + Benazepril Majeure
- Amiloride + Benazepril Majeure
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Majeure
Questions fréquentes
Can I take Benazepril with Empagliflozin-linagliptin?
MediHelp rates the interaction as moderate. Benazepril and Empagliflozin-linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. DPP-4 inhibitors such as linagliptin reduce breakdown of substance P and bradykinin, which are also affected by ACE inhibitors. Taking both may raise the risk of angioedema, though absolute risk remains small.
How serious is the interaction between Benazepril and Empagliflozin-linagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to report swelling of the lips, tongue or face immediately. Stop the ACE inhibitor and treat if angioedema occurs, and use an alternative antihypertensive class in patients with prior angioedema.
What other medicines interact with Empagliflozin-linagliptin?
MediHelp also lists interactions of Empagliflozin-linagliptin with, for example, Fosphenytoin, Rifampin, Rifapentine. The full list is on the Empagliflozin-linagliptin page.
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