Drug interactions
Bendroflumethiazide + Hydrochlorothiazide-lisinopril
Severity: Major
Bendroflumethiazide and Hydrochlorothiazide-lisinopril: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining two thiazide diuretics duplicates therapy and increases the risk of hypokalemia, hyponatremia, hypotension and renal impairment without clear added benefit.
What this interaction means in plain words
Bendroflumethiazide and Hydrochlorothiazide-lisinopril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Duplicate inhibition of the distal tubule sodium-chloride cotransporter with additive electrolyte loss and volume depletion.
What to do
Avoid using two thiazides together and stop one of them. Monitor electrolytes and renal function if overlap occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Candesartan + Hydrochlorothiazide-lisinopril Major
Frequently asked questions
Can I take Bendroflumethiazide with Hydrochlorothiazide-lisinopril?
MediHelp rates the interaction as major. Bendroflumethiazide and Hydrochlorothiazide-lisinopril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining two thiazide diuretics duplicates therapy and increases the risk of hypokalemia, hyponatremia, hypotension and renal impairment without clear added benefit.
How serious is the interaction between Bendroflumethiazide and Hydrochlorothiazide-lisinopril?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two thiazides together and stop one of them. Monitor electrolytes and renal function if overlap occurs.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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