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Interactions médicamenteuses

Bexarotene + Lorlatinib

Gravité: Majeure

Bexarotene and Lorlatinib: major interaction.

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Résumé

Bexarotene is a moderate CYP3A4 inducer and may lower lorlatinib levels, reducing efficacy. Lorlatinib has also been associated with hepatotoxicity when given with inducers.

Ce que signifie cette interaction, en termes simples

Bexarotene and Lorlatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Bexarotene belongs to Oncology; Lorlatinib belongs to Oncology.

Niveau de preuve: Moderate

Pourquoi elle survient

Bexarotene induces CYP3A4, increasing lorlatinib metabolism.

Conduite à tenir

Avoid the combination if possible. If it is used, monitor liver enzymes and bilirubin and watch for loss of response.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Bexarotene with Lorlatinib?

MediHelp rates the interaction as major. Bexarotene and Lorlatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Bexarotene is a moderate CYP3A4 inducer and may lower lorlatinib levels, reducing efficacy. Lorlatinib has also been associated with hepatotoxicity when given with inducers.

How serious is the interaction between Bexarotene and Lorlatinib?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If it is used, monitor liver enzymes and bilirubin and watch for loss of response.

What other medicines interact with Lorlatinib?

MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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