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MediHelp Référence médicamenteuse

Interactions médicamenteuses

Bexarotene + Gemfibrozil

Gravité: Majeure

Bexarotene and Gemfibrozil: major interaction.

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Résumé

Gemfibrozil has been associated with markedly raised bexarotene plasma concentrations in a labeling-described observation. Higher bexarotene exposure may worsen its dose-related toxicities such as hypertriglyceridemia, hypothyroidism and pancreatitis.

Ce que signifie cette interaction, en termes simples

Bexarotene and Gemfibrozil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Bexarotene belongs to Oncology; Gemfibrozil belongs to Cardiovascular.

Niveau de preuve: Moderate

Pourquoi elle survient

Proposed inhibition of CYP3A4-mediated and possibly other metabolic clearance of bexarotene by gemfibrozil; the mechanism is not firmly established.

Conduite à tenir

Avoid concomitant use; bexarotene labeling advises against it. If unavoidable, monitor lipids, triglycerides and pancreatitis symptoms closely.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Bexarotene with Gemfibrozil?

MediHelp rates the interaction as major. Bexarotene and Gemfibrozil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gemfibrozil has been associated with markedly raised bexarotene plasma concentrations in a labeling-described observation. Higher bexarotene exposure may worsen its dose-related toxicities such as hypertriglyceridemia, hypothyroidism and pancreatitis.

How serious is the interaction between Bexarotene and Gemfibrozil?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use; bexarotene labeling advises against it. If unavoidable, monitor lipids, triglycerides and pancreatitis symptoms closely.

What other medicines interact with Gemfibrozil?

MediHelp also lists interactions of Gemfibrozil with, for example, Daprodustat, Elagolix, Mavacamten. The full list is on the Gemfibrozil page.

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