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Interactions médicamenteuses

Bosentan + Sparsentan

Gravité: Contre-indiquée

Bosentan and Sparsentan: contraindicated interaction.

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Résumé

Sparsentan is itself a dual endothelin and angiotensin II receptor antagonist, so adding another endothelin receptor antagonist duplicates the pharmacology. This raises the risk of hypotension, syncope, hyperkalemia and deterioration of renal function, and may add to hepatotoxicity and fetal risk.

Ce que signifie cette interaction, en termes simples

Bosentan and Sparsentan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Bosentan belongs to Miscellaneous; Sparsentan belongs to Genitourinary.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive pharmacodynamic endothelin receptor blockade, with sparsentan also blocking the angiotensin II receptor.

Conduite à tenir

Do not combine; sparsentan labeling prohibits concomitant endothelin receptor antagonists. Choose one agent according to the indication.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Bosentan with Sparsentan?

MediHelp rates the interaction as contraindicated. Bosentan and Sparsentan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Sparsentan is itself a dual endothelin and angiotensin II receptor antagonist, so adding another endothelin receptor antagonist duplicates the pharmacology. This raises the risk of hypotension, syncope, hyperkalemia and deterioration of renal function, and may add to hepatotoxicity and fetal risk.

How serious is the interaction between Bosentan and Sparsentan?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; sparsentan labeling prohibits concomitant endothelin receptor antagonists. Choose one agent according to the indication.

What other medicines interact with Bosentan?

MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Cyclosporine, Glyburide. The full list is on the Bosentan page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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