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Interactions médicamenteuses

Bosentan + Lonafarnib

Gravité: Contre-indiquée

Bosentan and Lonafarnib: contraindicated interaction.

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Résumé

Lonafarnib is a sensitive CYP3A4 substrate, and bosentan as a moderate inducer may substantially reduce its exposure and effectiveness. Lonafarnib labeling contraindicates moderate and strong CYP3A inducers.

Ce que signifie cette interaction, en termes simples

Bosentan and Lonafarnib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Bosentan belongs to Miscellaneous; Lonafarnib belongs to Miscellaneous.

Niveau de preuve: Moderate

Pourquoi elle survient

CYP3A4 induction by bosentan increases lonafarnib clearance.

Conduite à tenir

Do not coadminister; use an alternative to bosentan.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Bosentan with Lonafarnib?

MediHelp rates the interaction as contraindicated. Bosentan and Lonafarnib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lonafarnib is a sensitive CYP3A4 substrate, and bosentan as a moderate inducer may substantially reduce its exposure and effectiveness. Lonafarnib labeling contraindicates moderate and strong CYP3A inducers.

How serious is the interaction between Bosentan and Lonafarnib?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; use an alternative to bosentan.

What other medicines interact with Bosentan?

MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Cyclosporine, Glyburide. The full list is on the Bosentan page.

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