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Interactions médicamenteuses

Brentuximab vedotin + Clarithromycin

Gravité: Modérée

Brentuximab vedotin and Clarithromycin: moderate interaction.

Dernière mise à jour

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Résumé

Strong CYP3A4 inhibition by clarithromycin can increase exposure to free MMAE, the cytotoxic component released from brentuximab vedotin. This may increase the risk of neutropenia and other toxicities.

Ce que signifie cette interaction, en termes simples

Brentuximab vedotin and Clarithromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Brentuximab vedotin belongs to Oncology; Clarithromycin belongs to Anti Bacterial.

Niveau de preuve: Moderate

Pourquoi elle survient

Clarithromycin inhibits CYP3A4, the main enzyme metabolizing MMAE released from the antibody-drug conjugate.

Conduite à tenir

Monitor closely for neutropenia and other adverse reactions. Consider an alternative antibiotic that does not inhibit CYP3A4.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Brentuximab vedotin with Clarithromycin?

MediHelp rates the interaction as moderate. Brentuximab vedotin and Clarithromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Strong CYP3A4 inhibition by clarithromycin can increase exposure to free MMAE, the cytotoxic component released from brentuximab vedotin. This may increase the risk of neutropenia and other toxicities.

How serious is the interaction between Brentuximab vedotin and Clarithromycin?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for neutropenia and other adverse reactions. Consider an alternative antibiotic that does not inhibit CYP3A4.

What other medicines interact with Clarithromycin?

MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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