Interactions médicamenteuses
Brentuximab vedotin + Siponimod
Gravité: Majeure
Brentuximab vedotin and Siponimod: major interaction.
Dernière mise à jour Sources: US FDA label
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Résumé
Brentuximab vedotin can cause neutropenia and serious infections, and it carries a risk of progressive multifocal leukoencephalopathy. Siponimod also carries infection and PML risk, so the combination may increase these concerns.
Ce que signifie cette interaction, en termes simples
Brentuximab vedotin and Siponimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Brentuximab vedotin belongs to Oncology; Siponimod belongs to Central Nervous System.
Pourquoi elle survient
Additive immunosuppression from S1P-mediated lymphocyte sequestration and cytotoxic antibody-drug conjugate myelosuppression.
Conduite à tenir
Avoid the combination if possible, or hold siponimod during brentuximab treatment. If used together, monitor neutrophil and lymphocyte counts and infection signs, including neurological symptoms suggesting PML.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Références
Autres interactions de Siponimod
- Cladribine + Siponimod Contre-indiquée
- Fingolimod + Siponimod Contre-indiquée
- Fluconazole + Siponimod Contre-indiquée
- Influenza virus vaccine quadrivalent intranasal + Siponimod Contre-indiquée
- Ponesimod + Siponimod Contre-indiquée
- Siponimod + Thioridazine Contre-indiquée
Autres interactions de Brentuximab vedotin
- Bleomycin + Brentuximab vedotin Contre-indiquée
- Apalutamide + Brentuximab vedotin Modérée
- Brentuximab vedotin + Clarithromycin Modérée
- Brentuximab vedotin + Imatinib Modérée
- Brentuximab vedotin + Isoniazid Modérée
- Brentuximab vedotin + Itraconazole Modérée
Questions fréquentes
Can I take Brentuximab vedotin with Siponimod?
MediHelp rates the interaction as major. Brentuximab vedotin and Siponimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Brentuximab vedotin can cause neutropenia and serious infections, and it carries a risk of progressive multifocal leukoencephalopathy. Siponimod also carries infection and PML risk, so the combination may increase these concerns.
How serious is the interaction between Brentuximab vedotin and Siponimod?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible, or hold siponimod during brentuximab treatment. If used together, monitor neutrophil and lymphocyte counts and infection signs, including neurological symptoms suggesting PML.
What other medicines interact with Siponimod?
MediHelp also lists interactions of Siponimod with, for example, Cladribine, Fingolimod, Fluconazole. The full list is on the Siponimod page.
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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
