Interactions médicamenteuses
Bumetanide + Carbenoxolone
Gravité: Majeure
Bumetanide and Carbenoxolone: major interaction.
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Résumé
Carbenoxolone has mineralocorticoid-like activity causing sodium retention and potassium loss, which adds to bumetanide-induced hypokalemia. Severe hypokalemia can cause arrhythmias and muscle weakness, and the sodium retention may oppose the diuretic effect.
Ce que signifie cette interaction, en termes simples
Bumetanide and Carbenoxolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Additive renal potassium wasting, with carbenoxolone causing mineralocorticoid-like sodium retention through inhibition of 11-beta-hydroxysteroid dehydrogenase.
Conduite à tenir
Avoid the combination where possible, or monitor serum potassium closely and replace potassium as required. Consider a potassium-sparing diuretic if both drugs must be continued.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Bumetanide
- Amifostine + Bumetanide Majeure
- Amikacin + Bumetanide Majeure
- Bumetanide + Captopril-hydrochlorothiazide Majeure
- Bumetanide + Cisplatin Majeure
- Bumetanide + Digoxin Majeure
- Bumetanide + Ethacrynic acid Majeure
Questions fréquentes
Can I take Bumetanide with Carbenoxolone?
MediHelp rates the interaction as major. Bumetanide and Carbenoxolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carbenoxolone has mineralocorticoid-like activity causing sodium retention and potassium loss, which adds to bumetanide-induced hypokalemia. Severe hypokalemia can cause arrhythmias and muscle weakness, and the sodium retention may oppose the diuretic effect.
How serious is the interaction between Bumetanide and Carbenoxolone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or monitor serum potassium closely and replace potassium as required. Consider a potassium-sparing diuretic if both drugs must be continued.
What other medicines interact with Bumetanide?
MediHelp also lists interactions of Bumetanide with, for example, Amifostine, Amikacin, Captopril-hydrochlorothiazide. The full list is on the Bumetanide page.
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