Interactions médicamenteuses
Bumetanide + Captopril-hydrochlorothiazide
Gravité: Majeure
Bumetanide and Captopril-hydrochlorothiazide: major interaction.
Dernière mise à jour
Réservé aux professionnels de santé — à titre de référence uniquement. Cette page est un bref résumé, pas un avis médical, et ne remplace ni la notice officielle ni le jugement clinique. Vérifiez toujours avant de prescrire ou de délivrer.
Le contenu clinique de cette page n'est disponible qu'en anglais.
Résumé
Combining a loop diuretic with a thiazide produces sequential nephron blockade, causing marked diuresis, hypokalemia, hyponatremia, hypomagnesemia and volume depletion. With captopril, hypotension and acute kidney injury are more likely.
Ce que signifie cette interaction, en termes simples
Bumetanide and Captopril-hydrochlorothiazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bumetanide belongs to Cardiovascular; Captopril-hydrochlorothiazide belongs to Cardiovascular.
Pourquoi elle survient
Additive natriuresis and potassium wasting at different nephron sites, with volume depletion potentiating ACE inhibitor hypotension and renal effects.
Conduite à tenir
Monitor electrolytes, creatinine, weight and blood pressure closely, particularly in the first weeks. Reduce diuretic doses or replace potassium and magnesium as needed.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Réservé aux membres Pro+
Débloquer la page complète
Créez un compte et lancez un essai Pro+ pour débloquer les conseils complets de prise en charge pour Bumetanide et Captopril-hydrochlorothiazide, les notes complémentaires, le détail des données probantes et le vérificateur d'interactions pour une ordonnance complète.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Essayez Pro+ gratuitement pendant 7 jours sur le web. Sans carte.
Autres interactions de Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contre-indiquée
- Captopril-hydrochlorothiazide + Dofetilide Contre-indiquée
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contre-indiquée
- Aceclofenac + Captopril-hydrochlorothiazide Majeure
- Aldesleukin + Captopril-hydrochlorothiazide Majeure
- Amifostine + Captopril-hydrochlorothiazide Majeure
Autres interactions de Bumetanide
- Amifostine + Bumetanide Majeure
- Amikacin + Bumetanide Majeure
- Bumetanide + Carbenoxolone Majeure
- Bumetanide + Cisplatin Majeure
- Bumetanide + Digoxin Majeure
- Bumetanide + Ethacrynic acid Majeure
Questions fréquentes
Can I take Bumetanide with Captopril-hydrochlorothiazide?
MediHelp rates the interaction as major. Bumetanide and Captopril-hydrochlorothiazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining a loop diuretic with a thiazide produces sequential nephron blockade, causing marked diuresis, hypokalemia, hyponatremia, hypomagnesemia and volume depletion. With captopril, hypotension and acute kidney injury are more likely.
How serious is the interaction between Bumetanide and Captopril-hydrochlorothiazide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor electrolytes, creatinine, weight and blood pressure closely, particularly in the first weeks. Reduce diuretic doses or replace potassium and magnesium as needed.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
