Interactions médicamenteuses
Bumetanide + Digoxin
Gravité: Majeure
Bumetanide and Digoxin: major interaction.
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Résumé
Bumetanide-induced hypokalemia and hypomagnesemia increase myocardial sensitivity to digoxin and can precipitate digoxin toxicity and arrhythmias. This is clinically important in heart failure patients who commonly take both.
Ce que signifie cette interaction, en termes simples
Bumetanide and Digoxin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bumetanide belongs to Cardiovascular; Digoxin belongs to Cardiovascular.
Pourquoi elle survient
Loop diuretic potassium and magnesium depletion enhances digoxin binding to Na+/K+-ATPase and arrhythmogenicity.
Conduite à tenir
Monitor serum potassium and magnesium regularly and keep them in the normal range with replacement as needed. Check digoxin levels and renal function if toxicity symptoms occur.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Bumetanide
- Amifostine + Bumetanide Majeure
- Amikacin + Bumetanide Majeure
- Bumetanide + Captopril-hydrochlorothiazide Majeure
- Bumetanide + Carbenoxolone Majeure
- Bumetanide + Cisplatin Majeure
- Bumetanide + Ethacrynic acid Majeure
Autres interactions de Digoxin
- Digoxin + Lily of the valley Contre-indiquée
- Digoxin + Squill Contre-indiquée
- Adagrasib + Digoxin Majeure
- Amiodarone + Digoxin Majeure
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Majeure
- Amphotericin b deoxycholate + Digoxin Majeure
Questions fréquentes
Can I take Bumetanide with Digoxin?
MediHelp rates the interaction as major. Bumetanide and Digoxin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Bumetanide-induced hypokalemia and hypomagnesemia increase myocardial sensitivity to digoxin and can precipitate digoxin toxicity and arrhythmias. This is clinically important in heart failure patients who commonly take both.
How serious is the interaction between Bumetanide and Digoxin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium regularly and keep them in the normal range with replacement as needed. Check digoxin levels and renal function if toxicity symptoms occur.
What other medicines interact with Bumetanide?
MediHelp also lists interactions of Bumetanide with, for example, Amifostine, Amikacin, Captopril-hydrochlorothiazide. The full list is on the Bumetanide page.
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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
