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Interactions médicamenteuses

Bumetanide + Cisplatin

Gravité: Majeure

Bumetanide and Cisplatin: major interaction.

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Résumé

Both drugs can damage the inner ear, and combined use may increase the risk or severity of hearing loss and tinnitus. Loop diuretic-induced volume depletion may also worsen cisplatin nephrotoxicity.

Ce que signifie cette interaction, en termes simples

Bumetanide and Cisplatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Bumetanide belongs to Cardiovascular; Cisplatin belongs to Oncology.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive ototoxicity via cochlear hair cell injury, with possible added renal toxicity from volume depletion.

Conduite à tenir

Avoid bumetanide where possible during cisplatin therapy; if needed, use the lowest dose, maintain hydration, and monitor hearing and renal function.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Bumetanide with Cisplatin?

MediHelp rates the interaction as major. Bumetanide and Cisplatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can damage the inner ear, and combined use may increase the risk or severity of hearing loss and tinnitus. Loop diuretic-induced volume depletion may also worsen cisplatin nephrotoxicity.

How serious is the interaction between Bumetanide and Cisplatin?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid bumetanide where possible during cisplatin therapy; if needed, use the lowest dose, maintain hydration, and monitor hearing and renal function.

What other medicines interact with Bumetanide?

MediHelp also lists interactions of Bumetanide with, for example, Amifostine, Amikacin, Captopril-hydrochlorothiazide. The full list is on the Bumetanide page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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