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Interactions médicamenteuses

Buprenorphine + Chlordiazepoxide-clidinium

Gravité: Majeure

Buprenorphine and Chlordiazepoxide-clidinium: major interaction.

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Résumé

Benzodiazepines combined with opioids such as buprenorphine can cause profound sedation, respiratory depression, coma and death. Regulators have issued boxed warnings for this class combination.

Ce que signifie cette interaction, en termes simples

Buprenorphine and Chlordiazepoxide-clidinium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Buprenorphine belongs to Musculoskeletal; Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract.

Niveau de preuve: High

Pourquoi elle survient

Additive CNS and respiratory depression via opioid and GABA-A receptor effects.

Conduite à tenir

Avoid the combination when possible; if necessary, use the lowest doses for the shortest duration. Monitor respiratory rate and sedation and counsel patients and caregivers about warning signs.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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  • Evidence detail
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Questions fréquentes

Can I take Buprenorphine with Chlordiazepoxide-clidinium?

MediHelp rates the interaction as major. Buprenorphine and Chlordiazepoxide-clidinium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Benzodiazepines combined with opioids such as buprenorphine can cause profound sedation, respiratory depression, coma and death. Regulators have issued boxed warnings for this class combination.

How serious is the interaction between Buprenorphine and Chlordiazepoxide-clidinium?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination when possible; if necessary, use the lowest doses for the shortest duration. Monitor respiratory rate and sedation and counsel patients and caregivers about warning signs.

What other medicines interact with Chlordiazepoxide-clidinium?

MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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