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Interactions médicamenteuses

Amobarbital + Chlordiazepoxide-clidinium

Gravité: Majeure

Amobarbital and Chlordiazepoxide-clidinium: major interaction.

Dernière mise à jour

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Résumé

Barbiturates and benzodiazepines together produce additive CNS and respiratory depression. Amobarbital also induces CYP3A4 and may lower chlordiazepoxide levels, making the net effect unpredictable.

Ce que signifie cette interaction, en termes simples

Amobarbital and Chlordiazepoxide-clidinium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Amobarbital belongs to Central Nervous System; Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive GABAergic CNS depression, with CYP3A4 induction by amobarbital altering chlordiazepoxide clearance.

Conduite à tenir

Avoid the combination where possible. If used, give reduced doses and monitor sedation and respiratory status.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Amobarbital with Chlordiazepoxide-clidinium?

MediHelp rates the interaction as major. Amobarbital and Chlordiazepoxide-clidinium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Barbiturates and benzodiazepines together produce additive CNS and respiratory depression. Amobarbital also induces CYP3A4 and may lower chlordiazepoxide levels, making the net effect unpredictable.

How serious is the interaction between Amobarbital and Chlordiazepoxide-clidinium?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If used, give reduced doses and monitor sedation and respiratory status.

What other medicines interact with Chlordiazepoxide-clidinium?

MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Belladonna and opium. The full list is on the Chlordiazepoxide-clidinium page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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