Référentiel des médicaments
Chlordiazepoxide-clidinium
Chlordiazepoxide-clidinium is a medicine in the class gastrointestinal tract. It is used for irritable bowel syndrome.
- Classe médicamenteuse: Gastrointestinal Tract
- Indications: irritable bowel syndrome
Dernière mise à jour
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Le contenu clinique de cette page n'est disponible qu'en anglais.
L'essentiel
- Classe médicamenteuse
- Gastrointestinal Tract
- Formes courantes
- comprimé, gélule
- Dosages courants
- 5 mg
- Interactions connues
- 231 (Majeure: 65 · Modérée: 134 · Mineure: 32)
- Noms commerciaux
- 11
- Pays et marchés
- 3
Indications
Mécanisme d'action
Chlordiazepoxide: Benzodiazepine; depresses all levels of CNS, including limbic and reticular formation, possibly by increasing gamma-aminobutyric acid (GABA) activity, a major inhibitory neurotransmitter. Clidinium: Anticholinergic agent; elicits antispasmodic and antisecretory effects on GI tract.
Posologie adulte habituelle (résumé de la notice)
Peptic Ulcer, IBS, & Enterocolitis: 1-2 cap PO q6-8hr AC and HS
Grossesse et allaitement
- Grossesse
- Unsafe Chlordiazepoxide: late-pregnancy use can cause neonatal sedation, floppiness and withdrawal; no clear birth-defect risk. Clidinium (anticholinergic): no adequate data. Avoid, especially near term; use only if clearly needed.
- Allaitement
- Unknown Chlordiazepoxide: no milk data; it and its long-acting metabolites could sedate the infant (LactMed: prefer an alternative). Clidinium, an anticholinergic, may reduce milk supply. Prefer alternatives; if used, watch the infant for sedation and poor feeding and watch milk supply.
Effets indésirables signalés
- Drowsiness
- Ataxia
- Xerostomia
Contre-indications
- Hypersensitivity
- Glaucoma
- Prostatic hypertrophy
Précautions particulières
- Contraindicated in Glaucoma, Prostatic hypertrophy, Severe respiratory depression.
- Concomitant use of benzodiazepines and opioids may result in profound respiratory depression, coma, and death.
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (231)
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
- Buprenorphine + Chlordiazepoxide-clidinium Major
- Buprenorphine buccal + Chlordiazepoxide-clidinium Major
- Buprenorphine long-acting + Chlordiazepoxide-clidinium Major
- Buprenorphine subdermal implant + Chlordiazepoxide-clidinium Major
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- Pharmacokinetics
- Patient counselling points
- Food interactions
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Autres médicaments de cette classe
Questions fréquentes
What is Chlordiazepoxide-clidinium used for?
Chlordiazepoxide-clidinium is a medicine in the class gastrointestinal tract. It is used for Irritable bowel syndrome, Peptic ulcer.
What side effects have been reported with Chlordiazepoxide-clidinium?
Drowsiness, Ataxia, Xerostomia.
Can Chlordiazepoxide-clidinium be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Chlordiazepoxide: late-pregnancy use can cause neonatal sedation, floppiness and withdrawal; no clear birth-defect risk. Clidinium (anticholinergic): no adequate data. Avoid, especially near term; use only if clearly needed. Breastfeeding: Unknown. Chlordiazepoxide: no milk data; it and its long-acting metabolites could sedate the infant (LactMed: prefer an alternative). Clidinium, an anticholinergic, may reduce milk supply. Prefer alternatives; if used, watch the infant for sedation and poor feeding and watch milk supply.
What does Chlordiazepoxide-clidinium interact with?
MediHelp lists 231 known interactions for Chlordiazepoxide-clidinium. Major: 65 · Moderate: 134 · Minor: 32. The most serious include Alfentanil, Alprazolam, Amobarbital.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
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