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Interactions médicamenteuses

Buprenorphine + Clobazam

Gravité: Majeure

Buprenorphine and Clobazam: major interaction.

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Résumé

Benzodiazepines combined with opioids such as buprenorphine can cause profound sedation, respiratory depression, coma and death. Regulators carry boxed warnings for this class combination.

Ce que signifie cette interaction, en termes simples

Buprenorphine and Clobazam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Buprenorphine belongs to Musculoskeletal; Clobazam belongs to Central Nervous System.

Niveau de preuve: High

Pourquoi elle survient

Additive CNS and respiratory depression via opioid receptors and GABA-A receptor modulation.

Conduite à tenir

Reserve concurrent use for patients without alternatives, using the lowest doses and shortest duration, and monitor for sedation and respiratory depression. Counsel patients and caregivers on warning signs, and consider naloxone availability.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Buprenorphine with Clobazam?

MediHelp rates the interaction as major. Buprenorphine and Clobazam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Benzodiazepines combined with opioids such as buprenorphine can cause profound sedation, respiratory depression, coma and death. Regulators carry boxed warnings for this class combination.

How serious is the interaction between Buprenorphine and Clobazam?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve concurrent use for patients without alternatives, using the lowest doses and shortest duration, and monitor for sedation and respiratory depression. Counsel patients and caregivers on warning signs, and consider naloxone availability.

What other medicines interact with Buprenorphine?

MediHelp also lists interactions of Buprenorphine with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan. The full list is on the Buprenorphine page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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