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Interactions médicamenteuses

Clobazam + Codeine

Gravité: Majeure

Clobazam and Codeine: major interaction.

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Résumé

Benzodiazepines combined with opioids carry a boxed warning for profound sedation, respiratory depression, coma and death. Clobazam may also weakly inhibit CYP2D6, which could reduce activation of codeine to morphine.

Ce que signifie cette interaction, en termes simples

Clobazam and Codeine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Clobazam belongs to Central Nervous System; Codeine belongs to Musculoskeletal.

Niveau de preuve: High

Pourquoi elle survient

Additive CNS and respiratory depression, plus possible CYP2D6 inhibition by clobazam.

Conduite à tenir

Avoid or limit to patients with no alternative, using the lowest doses and shortest duration. Monitor for sedation and respiratory depression, and consider naloxone.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Clobazam with Codeine?

MediHelp rates the interaction as major. Clobazam and Codeine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Benzodiazepines combined with opioids carry a boxed warning for profound sedation, respiratory depression, coma and death. Clobazam may also weakly inhibit CYP2D6, which could reduce activation of codeine to morphine.

How serious is the interaction between Clobazam and Codeine?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid or limit to patients with no alternative, using the lowest doses and shortest duration. Monitor for sedation and respiratory depression, and consider naloxone.

What other medicines interact with Codeine?

MediHelp also lists interactions of Codeine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Codeine page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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