Interactions médicamenteuses
Carisoprodol + Clobazam
Gravité: Majeure
Carisoprodol and Clobazam: major interaction.
Dernière mise à jour
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Résumé
Benzodiazepines and carisoprodol together cause additive CNS depression, which may result in marked sedation, impaired coordination and respiratory depression. Carisoprodol can also modestly affect CYP2C19 activity, which may alter clobazam's active metabolite exposure.
Ce que signifie cette interaction, en termes simples
Carisoprodol and Clobazam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carisoprodol belongs to Musculoskeletal; Clobazam belongs to Central Nervous System.
Pourquoi elle survient
Additive CNS depression through GABA-A enhancement.
Conduite à tenir
Avoid the combination where possible, or use the lowest effective doses and monitor for sedation and respiratory depression. Counsel against alcohol and driving.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Carisoprodol
- Alfentanil + Carisoprodol Majeure
- Alprazolam + Carisoprodol Majeure
- Amobarbital + Carisoprodol Majeure
- Baclofen + Carisoprodol Majeure
- Belladonna and opium + Carisoprodol Majeure
- Benzhydrocodone / acetaminophen + Carisoprodol Majeure
Autres interactions de Clobazam
- Amobarbital + Clobazam Majeure
- Buprenorphine + Clobazam Majeure
- Butorphanol + Clobazam Majeure
- Chloral hydrate + Clobazam Majeure
- Clobazam + Clozapine Majeure
- Clobazam + Codeine Majeure
Questions fréquentes
Can I take Carisoprodol with Clobazam?
MediHelp rates the interaction as major. Carisoprodol and Clobazam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Benzodiazepines and carisoprodol together cause additive CNS depression, which may result in marked sedation, impaired coordination and respiratory depression. Carisoprodol can also modestly affect CYP2C19 activity, which may alter clobazam's active metabolite exposure.
How serious is the interaction between Carisoprodol and Clobazam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or use the lowest effective doses and monitor for sedation and respiratory depression. Counsel against alcohol and driving.
What other medicines interact with Carisoprodol?
MediHelp also lists interactions of Carisoprodol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Carisoprodol page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
