Interactions médicamenteuses
Buprenorphine long-acting + Chlordiazepoxide-clidinium
Gravité: Majeure
Buprenorphine long-acting and Chlordiazepoxide-clidinium: major interaction.
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Résumé
Long-acting injectable buprenorphine with chlordiazepoxide can cause profound sedation, respiratory depression, coma and death. Exposure persists for weeks and cannot be rapidly reversed.
Ce que signifie cette interaction, en termes simples
Buprenorphine long-acting and Chlordiazepoxide-clidinium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Additive CNS and respiratory depression from opioid and benzodiazepine effects.
Conduite à tenir
Use only when alternatives are inadequate, and keep benzodiazepine doses minimal and short. Monitor for sedation and respiratory depression.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Majeure
- Alprazolam + Chlordiazepoxide-clidinium Majeure
- Amobarbital + Chlordiazepoxide-clidinium Majeure
- Belladonna and opium + Chlordiazepoxide-clidinium Majeure
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Majeure
- Brexanolone + Chlordiazepoxide-clidinium Majeure
Questions fréquentes
Can I take Buprenorphine long-acting with Chlordiazepoxide-clidinium?
MediHelp rates the interaction as major. Buprenorphine long-acting and Chlordiazepoxide-clidinium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Long-acting injectable buprenorphine with chlordiazepoxide can cause profound sedation, respiratory depression, coma and death. Exposure persists for weeks and cannot be rapidly reversed.
How serious is the interaction between Buprenorphine long-acting and Chlordiazepoxide-clidinium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only when alternatives are inadequate, and keep benzodiazepine doses minimal and short. Monitor for sedation and respiratory depression.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
