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Interactions médicamenteuses

Buspirone + Phenelzine

Gravité: Contre-indiquée

Buspirone and Phenelzine: contraindicated interaction.

Dernière mise à jour Sources: US FDA label

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Résumé

Buspirone with a nonselective MAOI such as phenelzine has been associated with hypertensive reactions and risk of serotonin syndrome. Buspirone labeling contraindicates its use with MAOIs. The reaction can be severe and may need hospital care.

Ce que signifie cette interaction, en termes simples

Buspirone and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Buspirone belongs to Central Nervous System; Phenelzine belongs to Central Nervous System.

Niveau de preuve: High

Pourquoi elle survient

Phenelzine inhibits MAO, raising monoamine levels, while buspirone is a serotonergic 5-HT1A partial agonist, so serotonergic toxicity may result; the hypertensive mechanism is not fully established.

Conduite à tenir

Do not use together. Allow at least 14 days after stopping phenelzine before starting buspirone, and about a week after stopping buspirone before starting an MAOI.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Références

Questions fréquentes

Can I take Buspirone with Phenelzine?

MediHelp rates the interaction as contraindicated. Buspirone and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Buspirone with a nonselective MAOI such as phenelzine has been associated with hypertensive reactions and risk of serotonin syndrome. Buspirone labeling contraindicates its use with MAOIs. The reaction can be severe and may need hospital care.

How serious is the interaction between Buspirone and Phenelzine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Allow at least 14 days after stopping phenelzine before starting buspirone, and about a week after stopping buspirone before starting an MAOI.

What other medicines interact with Phenelzine?

MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.

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