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Interactions médicamenteuses

Buspirone + Linezolid

Gravité: Contre-indiquée

Buspirone and Linezolid: contraindicated interaction.

Dernière mise à jour

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Résumé

Linezolid (an oxazolidinone antibiotic with weak, reversible MAO-inhibiting activity) added to buspirone, a serotonin 5-HT1A partial agonist, has been associated with raised blood pressure and with serotonergic toxicity. Buspirone labelling advises against concurrent MAOI use.

Ce que signifie cette interaction, en termes simples

Buspirone and Linezolid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Buspirone belongs to Central Nervous System; Linezolid belongs to Anti Bacterial.

Niveau de preuve: Moderate

Pourquoi elle survient

Combined serotonergic activity with MAO inhibition; possible pressor reaction

Conduite à tenir

Avoid the combination. Stop linezolid and wait roughly 24 hours (linezolid has a short half-life) before starting the other drug.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Buspirone with Linezolid?

MediHelp rates the interaction as contraindicated. Buspirone and Linezolid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Linezolid (an oxazolidinone antibiotic with weak, reversible MAO-inhibiting activity) added to buspirone, a serotonin 5-HT1A partial agonist, has been associated with raised blood pressure and with serotonergic toxicity. Buspirone labelling advises against concurrent MAOI use.

How serious is the interaction between Buspirone and Linezolid?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. Stop linezolid and wait roughly 24 hours (linezolid has a short half-life) before starting the other drug.

What other medicines interact with Linezolid?

MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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