Interactions médicamenteuses
Buspirone + Selegiline transdermal
Gravité: Contre-indiquée
Buspirone and Selegiline transdermal: contraindicated interaction.
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Résumé
Buspirone given with a monoamine oxidase inhibitor has been associated with marked elevations in blood pressure. Selegiline at antidepressant transdermal doses inhibits both MAO isoenzymes, so the risk is relevant and buspirone labeling prohibits MAOI use.
Ce que signifie cette interaction, en termes simples
Buspirone and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
MAO inhibition combined with buspirone's serotonergic and dopaminergic activity produces a pharmacodynamic effect leading to hypertensive reactions; the exact mechanism is not fully established.
Conduite à tenir
Avoid concurrent use; allow a washout of at least 2 weeks after stopping an MAOI before starting buspirone, and the reverse for selegiline.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Buspirone
- Buspirone + Isocarboxazid Contre-indiquée
- Buspirone + Linezolid Contre-indiquée
- Buspirone + Phenelzine Contre-indiquée
- Buspirone + Procarbazine Contre-indiquée
- Buspirone + Selegiline Contre-indiquée
- Buspirone + Tranylcypromine Contre-indiquée
Questions fréquentes
Can I take Buspirone with Selegiline transdermal?
MediHelp rates the interaction as contraindicated. Buspirone and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Buspirone given with a monoamine oxidase inhibitor has been associated with marked elevations in blood pressure. Selegiline at antidepressant transdermal doses inhibits both MAO isoenzymes, so the risk is relevant and buspirone labeling prohibits MAOI use.
How serious is the interaction between Buspirone and Selegiline transdermal?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; allow a washout of at least 2 weeks after stopping an MAOI before starting buspirone, and the reverse for selegiline.
What other medicines interact with Buspirone?
MediHelp also lists interactions of Buspirone with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Buspirone page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
