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Interactions médicamenteuses

Buspirone + Procarbazine

Gravité: Contre-indiquée

Buspirone and Procarbazine: contraindicated interaction.

Dernière mise à jour

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Résumé

Procarbazine (a cytotoxic drug with weak MAO-inhibiting activity) added to buspirone, a serotonin 5-HT1A partial agonist, has been associated with raised blood pressure and with serotonergic toxicity. Buspirone labelling advises against concurrent MAOI use.

Ce que signifie cette interaction, en termes simples

Buspirone and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Buspirone belongs to Central Nervous System; Procarbazine belongs to Oncology.

Niveau de preuve: Moderate

Pourquoi elle survient

Combined serotonergic activity with MAO inhibition; possible pressor reaction

Conduite à tenir

Avoid the combination. Wait at least 14 days after stopping procarbazine before starting the other drug.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Buspirone with Procarbazine?

MediHelp rates the interaction as contraindicated. Buspirone and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Procarbazine (a cytotoxic drug with weak MAO-inhibiting activity) added to buspirone, a serotonin 5-HT1A partial agonist, has been associated with raised blood pressure and with serotonergic toxicity. Buspirone labelling advises against concurrent MAOI use.

How serious is the interaction between Buspirone and Procarbazine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. Wait at least 14 days after stopping procarbazine before starting the other drug.

What other medicines interact with Buspirone?

MediHelp also lists interactions of Buspirone with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Buspirone page.

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