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Interactions médicamenteuses

Cabotegravir + Dolutegravir

Gravité: Majeure

Cabotegravir and Dolutegravir: major interaction.

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Résumé

Both are integrase strand transfer inhibitors, so the combination duplicates therapy without established benefit. Cabotegravir with rilpivirine is designed as a complete regimen.

Ce que signifie cette interaction, en termes simples

Cabotegravir and Dolutegravir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Cabotegravir belongs to Anti Virals; Dolutegravir belongs to Anti Virals.

Niveau de preuve: Low

Pourquoi elle survient

Pharmacodynamic duplication of integrase inhibitor therapy, with no established combination benefit.

Conduite à tenir

Do not combine; use a single integrase inhibitor within a complete regimen.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Cabotegravir with Dolutegravir?

MediHelp rates the interaction as major. Cabotegravir and Dolutegravir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are integrase strand transfer inhibitors, so the combination duplicates therapy without established benefit. Cabotegravir with rilpivirine is designed as a complete regimen.

How serious is the interaction between Cabotegravir and Dolutegravir?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; use a single integrase inhibitor within a complete regimen.

What other medicines interact with Dolutegravir?

MediHelp also lists interactions of Dolutegravir with, for example, Dofetilide, Aluminum hydroxide, Atidarsagene autotemcel. The full list is on the Dolutegravir page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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