Drug interactions
Cabotegravir + Dolutegravir
Severity: Major
Cabotegravir and Dolutegravir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are integrase strand transfer inhibitors, so the combination duplicates therapy without established benefit. Cabotegravir with rilpivirine is designed as a complete regimen.
What this interaction means in plain words
Cabotegravir and Dolutegravir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cabotegravir belongs to Anti Virals; Dolutegravir belongs to Anti Virals.
Why it happens
Pharmacodynamic duplication of integrase inhibitor therapy, with no established combination benefit.
What to do
Do not combine; use a single integrase inhibitor within a complete regimen.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dolutegravir
Other interactions of Cabotegravir
- Apalutamide + Cabotegravir Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Cabotegravir + Oxcarbazepine Contraindicated
- Cabotegravir + Phenobarbitone Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Cabotegravir + Rifabutin Contraindicated
Frequently asked questions
Can I take Cabotegravir with Dolutegravir?
MediHelp rates the interaction as major. Cabotegravir and Dolutegravir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are integrase strand transfer inhibitors, so the combination duplicates therapy without established benefit. Cabotegravir with rilpivirine is designed as a complete regimen.
How serious is the interaction between Cabotegravir and Dolutegravir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; use a single integrase inhibitor within a complete regimen.
What other medicines interact with Dolutegravir?
MediHelp also lists interactions of Dolutegravir with, for example, Dofetilide, Aluminum hydroxide, Atidarsagene autotemcel. The full list is on the Dolutegravir page.
Full monographs, dosing and an interaction checker in the MediHelp app
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