Interactions médicamenteuses
Calcium + Ceftriaxone
Gravité: Contre-indiquée
Calcium and Ceftriaxone: contraindicated interaction.
Dernière mise à jour Sources: US FDA label
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Résumé
Ceftriaxone can form insoluble ceftriaxone-calcium precipitates when mixed with or given alongside intravenous calcium. Fatal cases of pulmonary and renal calcium-ceftriaxone precipitation have occurred in neonates. Concurrent use is contraindicated in neonates up to 28 days old, and in older patients the two must not be mixed or given through the same line.
Ce que signifie cette interaction, en termes simples
Calcium and Ceftriaxone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Calcium belongs to Gastrointestinal Tract; Ceftriaxone belongs to Anti Bacterial.
Pourquoi elle survient
Ceftriaxone binds calcium to form an insoluble salt that precipitates in infusion lines and, in vivo, in lungs and kidneys.
Conduite à tenir
Do not give ceftriaxone with IV calcium-containing products (including parenteral nutrition) to neonates up to 28 days old.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Références
- Rocephin (ceftriaxone) Prescribing Information - Contraindications and Warnings — FDA Label
- Ceftriaxone powder for solution for injection/infusion - Summary of Product Characteristics — EMA SmPC
Autres interactions de Ceftriaxone
- Calcium chloride + Ceftriaxone Contre-indiquée
- Calcium gluconate + Ceftriaxone Contre-indiquée
- Ceftriaxone + Lactated ringer's Contre-indiquée
- Ceftriaxone + Ringer's solution Contre-indiquée
- Calcium acetate + Ceftriaxone Majeure
- Ceftriaxone + Lactated Ringer's solution Majeure
Autres interactions de Calcium
- Acalabrutinib + Calcium Modérée
- Alendronate + Calcium Modérée
- Atazanavir + Calcium Modérée
- Baloxavir marboxil + Calcium Modérée
- Bendroflumethiazide + Calcium Modérée
- Bictegravir + Calcium Modérée
Questions fréquentes
Can I take Calcium with Ceftriaxone?
MediHelp rates the interaction as contraindicated. Calcium and Ceftriaxone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ceftriaxone can form insoluble ceftriaxone-calcium precipitates when mixed with or given alongside intravenous calcium. Fatal cases of pulmonary and renal calcium-ceftriaxone precipitation have occurred in neonates. Concurrent use is contraindicated in neonates up to 28 days old, and in older patients the two must not be mixed or given through the same line.
How serious is the interaction between Calcium and Ceftriaxone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give ceftriaxone with IV calcium-containing products (including parenteral nutrition) to neonates up to 28 days old.
What other medicines interact with Ceftriaxone?
MediHelp also lists interactions of Ceftriaxone with, for example, Calcium chloride, Calcium gluconate, Lactated ringer's. The full list is on the Ceftriaxone page.
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