Interactions médicamenteuses
Ceftriaxone + Ringer's solution
Gravité: Contre-indiquée
Ceftriaxone and Ringer's solution: contraindicated interaction.
Dernière mise à jour Sources: US FDA label
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Résumé
Ceftriaxone can form an insoluble ceftriaxone-calcium precipitate when mixed with calcium-containing solutions such as Ringer's or lactated Ringer's. Fatal cases of crystalline deposits in the lungs and kidneys have occurred in neonates given ceftriaxone and calcium-containing intravenous fluids. In neonates the combination is contraindicated, and in older patients it must not be mixed or co-infused in the same line.
Ce que signifie cette interaction, en termes simples
Ceftriaxone and Ringer's solution are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
Ceftriaxone binds calcium to form poorly soluble ceftriaxone-calcium salt, which precipitates in IV lines and in vivo.
Conduite à tenir
Do not give ceftriaxone to neonates (up to 28 days) who need or are expected to need calcium-containing IV solutions, including Ringer's.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Références
- Rocephin (ceftriaxone) Prescribing Information - Contraindications and Warnings: Interaction with calcium-containing products — FDA Label
- Ceftriaxone Summary of Product Characteristics - Contraindications and Interactions with calcium — EMA SmPC
Autres interactions de Ceftriaxone
- Calcium chloride + Ceftriaxone Contre-indiquée
- Calcium gluconate + Ceftriaxone Contre-indiquée
- Calcium + Ceftriaxone Contre-indiquée
- Ceftriaxone + Lactated ringer's Contre-indiquée
- Calcium acetate + Ceftriaxone Majeure
- Ceftriaxone + Lactated Ringer's solution Majeure
Questions fréquentes
Can I take Ceftriaxone with Ringer's solution?
MediHelp rates the interaction as contraindicated. Ceftriaxone and Ringer's solution are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ceftriaxone can form an insoluble ceftriaxone-calcium precipitate when mixed with calcium-containing solutions such as Ringer's or lactated Ringer's. Fatal cases of crystalline deposits in the lungs and kidneys have occurred in neonates given ceftriaxone and calcium-containing intravenous fluids. In neonates the combination is contraindicated, and in older patients it must not be mixed or co-infused in the same line.
How serious is the interaction between Ceftriaxone and Ringer's solution?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give ceftriaxone to neonates (up to 28 days) who need or are expected to need calcium-containing IV solutions, including Ringer's.
What other medicines interact with Ceftriaxone?
MediHelp also lists interactions of Ceftriaxone with, for example, Calcium chloride, Calcium gluconate, Calcium. The full list is on the Ceftriaxone page.
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