Interactions médicamenteuses
Ceftriaxone + Lactated ringer's
Gravité: Contre-indiquée
Ceftriaxone and Lactated ringer's: contraindicated interaction.
Dernière mise à jour Sources: US FDA label
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Résumé
Ceftriaxone can form insoluble ceftriaxone-calcium precipitates when mixed with calcium-containing solutions such as lactated Ringer's. Fatal cases of lung and kidney crystal deposition have occurred in neonates. In neonates up to 28 days old, concurrent use is contraindicated, and in older patients the two must not be mixed or given simultaneously through the same line.
Ce que signifie cette interaction, en termes simples
Ceftriaxone and Lactated ringer's are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
Physicochemical incompatibility: ceftriaxone binds calcium to form insoluble ceftriaxone-calcium salt that can precipitate in lines and in vivo.
Conduite à tenir
Do not give ceftriaxone to neonates (28 days or younger) who are receiving or expected to receive calcium-containing IV solutions.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Références
- Rocephin (ceftriaxone) Prescribing Information - Contraindications and Warnings: Interaction with Calcium-Containing Products — FDA Label
- Ceftriaxone Summary of Product Characteristics - Contraindications — EMA SmPC
Autres interactions de Ceftriaxone
- Calcium chloride + Ceftriaxone Contre-indiquée
- Calcium gluconate + Ceftriaxone Contre-indiquée
- Calcium + Ceftriaxone Contre-indiquée
- Ceftriaxone + Ringer's solution Contre-indiquée
- Calcium acetate + Ceftriaxone Majeure
- Ceftriaxone + Lactated Ringer's solution Majeure
Questions fréquentes
Can I take Ceftriaxone with Lactated ringer's?
MediHelp rates the interaction as contraindicated. Ceftriaxone and Lactated ringer's are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ceftriaxone can form insoluble ceftriaxone-calcium precipitates when mixed with calcium-containing solutions such as lactated Ringer's. Fatal cases of lung and kidney crystal deposition have occurred in neonates. In neonates up to 28 days old, concurrent use is contraindicated, and in older patients the two must not be mixed or given simultaneously through the same line.
How serious is the interaction between Ceftriaxone and Lactated ringer's?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give ceftriaxone to neonates (28 days or younger) who are receiving or expected to receive calcium-containing IV solutions.
What other medicines interact with Ceftriaxone?
MediHelp also lists interactions of Ceftriaxone with, for example, Calcium chloride, Calcium gluconate, Calcium. The full list is on the Ceftriaxone page.
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