Drug interactions
Calcium Carbonate + Cholecalciferol
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Additive increase in calcium absorption and load, raising the risk of hypercalcemia and hypercalciuria when calcium salts are combined with vitamin D.
Mechanism of action
Pharmacodynamic: Vitamin D enhances intestinal calcium absorption; concurrent calcium supplementation increases total calcium availability.
Clinical management
Avoid excessive doses; use the minimum necessary to meet requirements. Monitor serum calcium (and urinary calcium in patients with nephrolithiasis risk) periodically, especially in CKD or when high-dose vitamin D is used. Reduce or hold one or both agents if hypercalcemia develops.
Drug reference
References
- Calcium Salts and Vitamin D Analogues: Drug Interactions — Lexicomp
- Calcichew D3 (calcium carbonate/cholecalciferol) SmPC – Sections 4.4 and 4.5 — EMA
- Vitamin D supplementation in adults: Adverse effects and toxicity — UpToDate
Frequently asked questions
Can I take Calcium Carbonate with Cholecalciferol?
The interaction is rated: Moderate. Additive increase in calcium absorption and load, raising the risk of hypercalcemia and hypercalciuria when calcium salts are combined with vitamin D.
How serious is the interaction between Calcium Carbonate and Cholecalciferol?
The interaction is rated: Moderate. Evidence level: High.
How is the interaction between Calcium Carbonate and Cholecalciferol managed?
Avoid excessive doses; use the minimum necessary to meet requirements. Monitor serum calcium (and urinary calcium in patients with nephrolithiasis risk) periodically, especially in CKD or when high-dose vitamin D is used. Reduce or hold one or both agents if hypercalcemia develops.
Why do Calcium Carbonate and Cholecalciferol interact?
Pharmacodynamic: Vitamin D enhances intestinal calcium absorption; concurrent calcium supplementation increases total calcium availability.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.