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Interactions médicamenteuses

Canagliflozin-metformin + Liothyronine

Gravité: Modérée

Canagliflozin-metformin and Liothyronine: moderate interaction.

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Résumé

Thyroid hormones can raise blood glucose and increase insulin requirements in diabetes. Starting or increasing liothyronine may reduce the effect of canagliflozin-metformin.

Ce que signifie cette interaction, en termes simples

Canagliflozin-metformin and Liothyronine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Canagliflozin-metformin belongs to Endocrine; Liothyronine belongs to Endocrine.

Niveau de preuve: Moderate

Pourquoi elle survient

Thyroid hormone increases hepatic glucose output, gut glucose absorption and metabolic rate, opposing antidiabetic therapy.

Conduite à tenir

Monitor blood glucose when starting or changing the liothyronine dose. Adjust antidiabetic therapy as needed.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Canagliflozin-metformin with Liothyronine?

MediHelp rates the interaction as moderate. Canagliflozin-metformin and Liothyronine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thyroid hormones can raise blood glucose and increase insulin requirements in diabetes. Starting or increasing liothyronine may reduce the effect of canagliflozin-metformin.

How serious is the interaction between Canagliflozin-metformin and Liothyronine?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or changing the liothyronine dose. Adjust antidiabetic therapy as needed.

What other medicines interact with Canagliflozin-metformin?

MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.

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